Microporous/Drug Delivery Balloons - Intellectual Property

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Additional Intellectual Property Rights owned by Advanced Polymers:

In May, 2001, Advanced Polymers, Inc., acquired the exclusive right, title and interest in and to IP previously owned by E-Med (Cor-Trak). These patents are available for license from Advanced Polymers, Inc. (Inquiries should be directed to Tricia L. Albert)

Patent No.

Patent Name

5,282,785

Drug Delivery Apparatus and Method

A drug delivery apparatus and method for delivering a drug locally to internal body tissue. The invention contemplates positioning a drug delivery device in a body passageway or within body tissue and then selectively introducing a selected drug so that it is transported across a drug transport wall of the device for direct contact with the passageway all or body tissue. A further aspect of the present invention involves treating a dilated vessel in the area of a stenotic lesion with a fixative or other drug to render the vessel biologically inert and to form a biological stent or prevent restenosis using specifically selected drugs. A still further aspect of the present invention involves treating a tumor or local or regional tissue mass with antitumor sensitizing agents, biological modifiers, antibiotics or other types of drugs by delivery of the drug to the tumor or tissue area directly or through the passageway wall.

5,286,254

Drug Delivery Apparatus and Method

5,458,568

Porous Balloon for Selective Dilatation and Drug Delivery

A drug delivery apparatus and method for delivering a drug locally to internal body tissue. The invention contemplates positioning a drug delivery device in a body passageway or within body tissue and then selectively wetting a membrane within the device, making the membrane permeable and allowing transport of a drug across the membrane and into the passageway wall or body tissue.

5,498,238

Simultaneous Angioplasty and Phoretic Drug Delivery

A method of simultaneous angioplasty and drug delivery to a localized portion of coronary or peripheral arteries or any other type of body passage that has a stricture. The invention contemplates positioning a drug delivery device in a body passageway and then selectively introducing a selected drug so that the device is expanded in order to dilate the passage and then simultaneously causing the drug to be transported across a drug transport wall of the device for direct contact with the passageway wall. A more specific aspect of the present invention involves treating a dilated vessel in the area of a stenotic lesion with a fixative or other drug to render the vessel biologically inert and to form a biological stent or prevent restenosis using specifically selected drugs.

5,499,971

Method for Iontophoretically Delivering Drug Adjacent to a Heart

A drug delivery apparatus and method for iontophoretically delivering a drug locally to internal body tissue. The iontophoretic delivery apparatus and method include a current source producing a net flow of current in a desired direction with high frequency waveforms which enhance delivery and minimize side effects typically associated with iontophoresis.

5,569,198

Microporous Catheter

An apparatus for delivering an agent to a treatment area. The apparatus includes a catheter that has a distal portion and a proximal portion. The catheter defines a lumen. A pressure regulator is in fluid communication with the lumen. A selectively inflatable member is also in fluid communication with the lumen, and is formed from a membrane. The membrane has first and second portions. The first portion defines pores sized from about 0.05 to about 1 and has a pore density from about 106 pores/cm2 to about 109 pores/cm2. the flux rate is from about 0.001 ml/(min*cm2*atm) to about 0.4 ml/(min*cm2*atm). The second portion is substantially impermeable.

5,628,730

Phoretic Balloon Catheter with Hydrogel Coating

A drug delivery apparatus and method for delivering a drug locally to internal body tissue. The invention contemplates positioning a drug delivery device in a body passageway or within body tissue and then selectively introducing a selected drug so that it is transported across a drug transport wall of the device for direct contact with the passageway wall or body tissue. A further aspect of the present invention involves treating a dilated vessel in the area of a stenotic lesion with a fixative or other drug to render the vessel biologically inert and to form a biological stent or prevent restenosis using specifically selected drugs. A still further aspect of the present invention involves treating a tumor or local or regional tissue mass with antitumor sensitizing agents, biological modifiers, antibiotics or other types of drugs by delivery of the drug to the tumor or tissue area directly or through the passageway wall.

5,634,899

Simultaneous Cardiac Pacing and Local Drug Delivery Method

An apparatus and method for delivering a drug selectively and locally to internal body tissue with a catheter using electric current/voltage controlled in conjunction with active pacing of cardiac activity.

5,800,392

Microporous Catheter

5,807,306

Polymer Matrix Drug Delivery Apparatus

A drug delivery apparatus and method for delivering a drug locally to internal body tissue using a catheter device including a polymer matrix containing a drug. The drug is actively transported from the polymer matrix to the internal body tissue using iontophoresis or phonophoresis. In addition, the polymer matrix can be expanded to promote intimate contact with the walls of a passageway or vessel.

5,865,787

Simultaneous Cardiac Pacing and Local Drug Delivery

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